Contralaterally controlled neuromuscular electrical stimulation-induced changes in functional connectivity in patients with stroke assessed using functional near-infrared spectroscopy

• Published in: Frontiers in neural circuits Vol. 16; p. 955728
• Main Authors: Guo, Chuan, Sui, Youxin, Xu, Sheng, Zhuang, Ren, Zhang, Mingming, Zhu, Shizhe, Wang, Jin, Zhang, Yushi, Kan, Chaojie, Shi, Ye, Wang, Tong, Shen, Ying
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 29.08.2022; Frontiers Media S.A
• Subjects: Cortex (motor); Cortex (somatosensory); Electric Stimulation; Electrical stimuli; Electrodes; Electromyography; Experiments; functional connectivity; functional near-infrared spectroscopy; Hemispheric laterality; Hemoglobin; Humans; I.R. radiation; Infrared spectroscopy; Medical research; Motor Cortex - physiology; Neural networks; Neuromuscular electrical stimulation; Neuroscience; Oxygenation; Patients; Prefrontal cortex; Range of motion; Rehabilitation; Sensorimotor system; Spectroscopy, Near-Infrared; Spectrum analysis; Stroke; Stroke - therapy; Stroke Rehabilitation - methods; Therapy; upper extremity; Wrist; wrist extension; China; neuromuscular electrical stimulation; functional connectivity; stroke; functional near-infrared spectroscopy; upper extremity; wrist extension
• ISSN: 1662-5110; 1662-5110
• DOI: 10.3389/fncir.2022.955728

Contralaterally controlled neuromuscular electrical stimulation (CCNMES) is an innovative therapy in stroke rehabilitation which has been verified in clinical studies. However, the underlying mechanism of CCNMES are yet to be comprehensively revealed. The main purpose of this study was to apply functional near-infrared spectroscopy (fNIRS) to compare CCNMES-related changes in functional connectivity (FC) within a cortical network after stroke with those induced by neuromuscular electrical stimulation (NMES) when performing wrist extension with hemiplegic upper extremity. Thirty-one stroke patients with right hemisphere lesion were randomly assigned to CCNMES ( = 16) or NMES ( = 15) groups. Patients in both groups received two tasks: 10-min rest and 10-min electrical stimulation task. In each task, the cerebral oxygenation signals in the prefrontal cortex (PFC), bilateral primary motor cortex (M1), and primary sensory cortex (S1) were measured by a 35-channel fNIRS. Compared with NMES, FC between ipsilesional M1 and contralesional M1/S1 were significantly strengthened during CCNMES. Additionally, significantly higher coupling strengths between ipsilesional PFC and contralesional M1/S1 were observed in the CCNMES group. Our findings suggest that CCNMES promotes the regulatory functions of ipsilesional prefrontal and motor areas as well as contralesional sensorimotor areas within the functional network in patients with stroke.