Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions

Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermo...

Full description

Saved in:
Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 21; no. 1; pp. 12 - E12
Main Authors El Ashry, El, El Kilany, Yeldez, Nahas, Nariman, Barakat, Assem, Al-Qurashi, Nadia, Ghabbour, Hazem, Fun, Hoong-Kun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.12.2015
MDPI
Subjects
Alkylation
benzimidazole-thione
Benzimidazoles - chemical synthesis
Benzimidazoles - chemistry
Chemistry
Crystallography, X-Ray
Hydrogen Bonding
Models, Molecular
Molecular Structure
Potassium
Solvents
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
thiazino[3,2-a]benzimidazole
X-ray
Saudi Arabia
Riyadh Saudi Arabia
thiazino[3,2-a]benzimidazole
X-ray
benzimidazole-thione
Online AccessGet full text

Cover

Abstract Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively.
AbstractList Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2 H -[1,3]thiazino[3,2- a ]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1 H-NMR, 13 C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P 2 1 / c , respectively.
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively.
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, ¹H-NMR, (13)C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P2₁/c, respectively.
Author El Kilany, Yeldez
Fun, Hoong-Kun
Nahas, Nariman
Barakat, Assem
Ghabbour, Hazem
Al-Qurashi, Nadia
El Ashry, El
AuthorAffiliation 2 Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia; narinahas@hotmail.com (N.M.N.); maam10@hotmail.com (N.A.-Q.)
3 Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
4 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia; ghabbourh@yahoo.com (H.A.G.); hfun.c@ksu.edu.sa (H.-K.F.)
1 Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt; yeldez244@hotmail.com (Y.E.K.); ambarakat@ksu.edu.sa (A.B.)
AuthorAffiliation_xml – name: 3 Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
– name: 1 Chemistry Department, Faculty of Science, Alexandria University, P. O. Box 426, Alexandria 21321, Egypt; yeldez244@hotmail.com (Y.E.K.); ambarakat@ksu.edu.sa (A.B.)
– name: 2 Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia; narinahas@hotmail.com (N.M.N.); maam10@hotmail.com (N.A.-Q.)
– name: 4 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia; ghabbourh@yahoo.com (H.A.G.); hfun.c@ksu.edu.sa (H.-K.F.)
Author_xml – sequence: 1
  givenname: El
  orcidid: 0000-0001-5480-239X
  surname: El Ashry
  fullname: El Ashry, El
– sequence: 2
  givenname: Yeldez
  surname: El Kilany
  fullname: El Kilany, Yeldez
– sequence: 3
  givenname: Nariman
  surname: Nahas
  fullname: Nahas, Nariman
– sequence: 4
  givenname: Assem
  orcidid: 0000-0002-7885-3201
  surname: Barakat
  fullname: Barakat, Assem
– sequence: 5
  givenname: Nadia
  surname: Al-Qurashi
  fullname: Al-Qurashi, Nadia
– sequence: 6
  givenname: Hazem
  orcidid: 0000-0002-1011-0276
  surname: Ghabbour
  fullname: Ghabbour, Hazem
– sequence: 7
  givenname: Hoong-Kun
  surname: Fun
  fullname: Fun, Hoong-Kun
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26703551$$D View this record in MEDLINE/PubMed
BookMark eNp1kk1vFSEUhompsR_6A9yYSdy4GeVzYDYm9frVpImJ1a2EYaCXKwMtMDeZ_nppb2vaGtmcA7zn4Q3nHIK9EIMB4CWCbwnp4bspeqNnbzJGEEGI8BNwgCiGLYG037uX74PDnDcQYkQRewb2ccchYQwdgF9nSyhrk11uVBibVVpyUb45K2nWZU4mN9E2H0y4cpMb1VV9sMVtWbtqpPloktuq4rZVNSzNsf-9-LqNoflulL5O8nPw1CqfzYvbeAR-fv70Y_W1Pf325WR1fNpq2pPScsas0XhEnUDDqE1dmFgohBjpoKiwmGiIBoowr7GzAjPdCUg1sWwkBpEjcLLjjlFt5EVyk0qLjMrJm4OYzqVKxWlvJGEKE6XwwC2liAjFLOsRp5UIORS2st7vWBfzMJnqJpSk_APow5vg1vI8bmWHORGMVcCbW0CKl7PJRU4ua-O9CibOWSLOUN9zDHGVvn4k3cQ5hfpVVdVRwhEmpKpe3Xf018pdG6uA7wQ6xZyTsVK7ctOKatB5iaC8Hhj5z8DUSvSo8g7-_5o_l27Gpw
CitedBy_id crossref_primary_10_1016_j_molstruc_2021_131043
crossref_primary_10_1080_08820538_2023_2233601
crossref_primary_10_1080_13816810_2020_1868013
crossref_primary_10_1002_slct_202102398
crossref_primary_10_3390_molecules27196268
crossref_primary_10_1111_cxo_13044
crossref_primary_10_1107_S2056989022008933
crossref_primary_10_3109_02713683_2015_1133831
crossref_primary_10_1177_1468678319825740
crossref_primary_10_1039_C9OB02548K
crossref_primary_10_3390_cryst10100955
crossref_primary_10_3390_ma15072544
crossref_primary_10_1080_17469899_2024_2368801
crossref_primary_10_1016_j_arabjc_2016_12_003
crossref_primary_10_1016_j_molstruc_2024_141027
crossref_primary_10_1016_j_ejmech_2023_115146
crossref_primary_10_1186_s40662_016_0047_5
crossref_primary_10_1016_j_poly_2022_116004
crossref_primary_10_1080_15421406_2022_2031449
crossref_primary_10_1016_j_tet_2021_132430
crossref_primary_10_1007_s10593_023_03206_x
crossref_primary_10_1080_02713683_2022_2088798
crossref_primary_10_1155_2019_7145857
Cites_doi 10.1080/15257770.2010.501777
10.1002/jhet.5570200363
10.1002/jhet.5570190350
10.1248/cpb.37.962
10.1007/BF01988005
10.1107/S0567740876003026
10.1007/BF02757443
10.1016/S0140-6736(83)92533-3
10.1021/jm00067a016
10.1016/j.ejmech.2010.01.007
10.1515/HC.2006.12.3-4.273
10.1111/j.1439-0507.1986.tb03958.x
10.1007/BF01537225
10.1128/AAC.39.1.175
ContentType Journal Article
Copyright Copyright MDPI AG 2016
2015 by the authors. 2015
Copyright_xml – notice: Copyright MDPI AG 2016
– notice: 2015 by the authors. 2015
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.3390/molecules21010012
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
ProQuest Central
ProQuest One
ProQuest Central Korea
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database
MEDLINE

MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1420-3049
EndPage E12
ExternalDocumentID oai_doaj_org_article_35a23aa2b7f44138a5f591745c60708f
PMC6273855
3948841561
26703551
10_3390_molecules21010012
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Saudi Arabia
Riyadh Saudi Arabia
GeographicLocations_xml – name: Saudi Arabia
– name: Riyadh Saudi Arabia
GroupedDBID ---
0R~
123
2WC
53G
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACIWK
ACPRK
ACUHS
AEGXH
AENEX
AFKRA
AFPKN
AFRAH
AFZYC
AIAGR
ALIPV
ALMA_UNASSIGNED_HOLDINGS
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
E3Z
EBD
EMOBN
ESX
FYUFA
GROUPED_DOAJ
GX1
HH5
HMCUK
HYE
HZ~
I09
IHR
IPNFZ
KQ8
LK8
M1P
MODMG
O-U
O9-
OK1
P2P
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RPM
SV3
TR2
TUS
UKHRP
~8M
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
8FK
AZQEC
DWQXO
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c493t-755fec2d1681bdceeee23f0888d4ba48f23c01b4127c016f825c6804c3f5d3e13
IEDL.DBID DOA
ISSN 1420-3049
IngestDate Wed Aug 27 01:29:21 EDT 2025
Thu Aug 21 14:06:13 EDT 2025
Thu Jul 10 23:12:21 EDT 2025
Fri Jul 25 03:46:27 EDT 2025
Thu Apr 03 06:54:17 EDT 2025
Tue Jul 01 03:11:15 EDT 2025
Thu Apr 24 23:01:57 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords thiazino[3,2-a]benzimidazole
X-ray
benzimidazole-thione
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c493t-755fec2d1681bdceeee23f0888d4ba48f23c01b4127c016f825c6804c3f5d3e13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors contributed equally to this work.
ORCID 0000-0002-7885-3201
0000-0002-1011-0276
0000-0001-5480-239X
OpenAccessLink https://doaj.org/article/35a23aa2b7f44138a5f591745c60708f
PMID 26703551
PQID 1764371233
PQPubID 2032355
ParticipantIDs doaj_primary_oai_doaj_org_article_35a23aa2b7f44138a5f591745c60708f
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6273855
proquest_miscellaneous_1751997202
proquest_journals_1764371233
pubmed_primary_26703551
crossref_citationtrail_10_3390_molecules21010012
crossref_primary_10_3390_molecules21010012
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20151222
PublicationDateYYYYMMDD 2015-12-22
PublicationDate_xml – month: 12
  year: 2015
  text: 20151222
  day: 22
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Molecules (Basel, Switzerland)
PublicationTitleAlternate Molecules
PublicationYear 2015
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Berg (ref_1) 1986; 29
Iemura (ref_5) 1989; 37
Suri (ref_23) 1983; 20
Benavides (ref_6) 1995; 45
Shingalapur (ref_18) 2010; 45
Lubenets (ref_17) 2000; 36
Graham (ref_8) 1990; 35
Saxena (ref_22) 1982; 19
Niemegeers (ref_4) 1986; 18
Chimirri (ref_3) 1991; 46
Elrayess (ref_15) 2013; 10
Saimot (ref_2) 1983; 322
Janssen (ref_12) 1968; 18
ref_20
Wiedemann (ref_10) 1984; 35
Ishihara (ref_7) 1994; 44
Piazzesi (ref_9) 1987; 37
Parras (ref_21) 1995; 39
Aly (ref_13) 2010; 29
Form (ref_16) 1976; B32
Kubo (ref_11) 1993; 36
Bakavoli (ref_14) 2006; 12
Narkhede (ref_19) 2008; 67
References_xml – volume: 35
  start-page: 964
  year: 1984
  ident: ref_10
  article-title: Pharmacokinetics of adimolol after single and multiple dose administration in healthy volunteers
  publication-title: Arzneim. Forsch.
– volume: 18
  start-page: 261
  year: 1968
  ident: ref_12
  article-title: Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol, and chlorpromazine
  publication-title: Arzneim. Forsch.
– volume: 29
  start-page: 698
  year: 2010
  ident: ref_13
  article-title: Revisit to the reaction of o-phenylene diamine with thiosemicarbazide to give benzimidazole-2-thione rather than benzotriazine-2-thione and its glycosylation
  publication-title: Nucleosides Nucleotides Nucleic Acids
  doi: 10.1080/15257770.2010.501777
– volume: 20
  start-page: 813
  year: 1983
  ident: ref_23
  article-title: Synthesis and spectral studies of 2-mercaptobenzimidazole derivatives 2
  publication-title: J. Heterocycl. Chem.
  doi: 10.1002/jhet.5570200363
– volume: 19
  start-page: 681
  year: 1982
  ident: ref_22
  article-title: Synthesis and spectral studies of 2-mercaptobenzimidazole derivatives 1
  publication-title: J. Heterocycl. Chem.
  doi: 10.1002/jhet.5570190350
– volume: 37
  start-page: 962
  year: 1989
  ident: ref_5
  article-title: Syntheses of the metabolites of 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole difumarate (KG-2413) and related compounds
  publication-title: Chem. Pharm. Bull.
  doi: 10.1248/cpb.37.962
– volume: 18
  start-page: 141
  year: 1986
  ident: ref_4
  article-title: The pharmacological profile of a specific, safe, effective and non-sedative anti-allergic, astemizole
  publication-title: Agents Actions
  doi: 10.1007/BF01988005
– volume: B32
  start-page: 345
  year: 1976
  ident: ref_16
  article-title: The crystal and molecular structure of 2-mercaptobenzimidazole
  publication-title: Acta Cryst.
  doi: 10.1107/S0567740876003026
– volume: 36
  start-page: 851
  year: 2000
  ident: ref_17
  article-title: Synthesis of thiosulfonates belonging to quinoline derivatives
  publication-title: Russ. J. Electrochem.
  doi: 10.1007/BF02757443
– volume: 322
  start-page: 652
  year: 1983
  ident: ref_2
  article-title: Albendazole as a potential treatment for human hydatidosis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(83)92533-3
– volume: 36
  start-page: 2182
  year: 1993
  ident: ref_11
  article-title: Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00067a016
– volume: 37
  start-page: 1141
  year: 1987
  ident: ref_9
  article-title: Effect of sulmazole and pimobendan on contractility of skinned fibres from frog skeletal muscle
  publication-title: Arzneim. Forsch.
– volume: 67
  start-page: 374
  year: 2008
  ident: ref_19
  article-title: Solid supported synthesis of 2-mercaptobenzimidazole derivatives using microwaves
  publication-title: J. Sci. Ind. Res.
– volume: 44
  start-page: 827
  year: 1994
  ident: ref_7
  article-title: Effect on gastric mucus of the proton pump inhibitor leminoprazole and its cytoprotective action against ethanol-induced gastric injury in rats
  publication-title: Arzneim. Forsch.
– volume: 46
  start-page: 817
  year: 1991
  ident: ref_3
  article-title: Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo [3,4-a] benzimidazoles
  publication-title: Farmaco
– volume: 45
  start-page: 551
  year: 1995
  ident: ref_6
  article-title: In vivo and in vitro interaction of the novel selective histamine H1 receptor antagonist mizolastine with H1 receptors in the rodent
  publication-title: Arzneim. Forsch.
– volume: 10
  start-page: 1784
  year: 2013
  ident: ref_15
  article-title: Synthesis and antimicrobial activities of some novel benzimidazole and benzotriazole derivatives containing β-lactam moiety
  publication-title: Life Sci. J.
– volume: 45
  start-page: 1753
  year: 2010
  ident: ref_18
  article-title: Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2010.01.007
– ident: ref_20
– volume: 12
  start-page: 273
  year: 2006
  ident: ref_14
  article-title: Reinvestigation of o-phenylenediamine thermal cyclocondensation with thiosemicarbazide
  publication-title: Heterocycl. Commun.
  doi: 10.1515/HC.2006.12.3-4.273
– volume: 29
  start-page: 221
  year: 1986
  ident: ref_1
  article-title: Action mechanisms of cell-division-arresting benzimidazoles and of sterol biosynthesis-inhibiting imidazoles, 1,2,4-triazoles, and pyrimidines
  publication-title: Mycoses
  doi: 10.1111/j.1439-0507.1986.tb03958.x
– volume: 35
  start-page: 66
  year: 1990
  ident: ref_8
  article-title: Omeprazole versus placebo in duodenal ulcer healing
  publication-title: Dig. Dis. Sci.
  doi: 10.1007/BF01537225
– volume: 39
  start-page: 175
  year: 1995
  ident: ref_21
  article-title: Comparative study of mupirocin and oral co-trimoxazole plus topical fusidic acid in eradication of nasal carriage of methicillin-resistant Staphylococcus aureus
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.39.1.175
SSID ssj0021415
Score 2.2219691
Snippet Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were...
Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2 H -[1,3]thiazino[3,2- a ]benzimidazole were...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 12
SubjectTerms Alkylation
benzimidazole-thione
Benzimidazoles - chemical synthesis
Benzimidazoles - chemistry
Chemistry
Crystallography, X-Ray
Hydrogen Bonding
Models, Molecular
Molecular Structure
Potassium
Solvents
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
thiazino[3,2-a]benzimidazole
X-ray
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB5BOcClKu-0BRmJE5LV-BWnJ9QuVBUHDpRKeyKyHZuu2GbbZltp--uZSbJbFlBziRQ70sQej7_xTL4BeK-VDybWgSenNNfSJu6LXPOUgilF1KRUlG3xtTg-1V_GZjwcuLVDWuXSJnaGup4FOiPfE5ZCTGhn1ceLS05Voyi6OpTQeAiPiLqMUrrs-M7hErg79ZFMha793nlfcDa26OYQ9ZBc24s6yv7_4cy_0yX_2H-OtmBzAI7soJ_pp_AgNs_g8WhZr-05_DhZNIjm2knLXFOz0dUCgd-UnXQEsdfoVbNZYoexuZ2cT2p3i1JyyednxFTEPqEe3nQU4C3zC3Yw_bXoc-TYt9j_-dC-gNOjz99Hx3yonsCD3ldzbo1JMchaFIhMUXa8pEpoVMpae6fLJFXIhddCWrwXCV3FUJS5DiqZWkWhXsJGgyK8BiaIMabwItb7XntBxcmiy32yCFcQQNgM8uU4VmGgFqcKF9MKXQwa-uqfoc_gw-qVi55X477OhzQ5q45Eid09mF39rIYVVinjpHJOepsQ4qnSmWTQF9X4VWjWypTB7nJqq2GdttWdVmXwbtWME0dhE9fE2TX1MZSNI3OU41WvCStJZIEWE0FnBnZNR9ZEXW9pJmcdi3fREQmZ7fvF2oEnOMKGEmik3IUN1Jn4BmHQ3L_tdP031jkKqQ
  priority: 102
  providerName: ProQuest
Title Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
URI https://www.ncbi.nlm.nih.gov/pubmed/26703551
https://www.proquest.com/docview/1764371233
https://www.proquest.com/docview/1751997202
https://pubmed.ncbi.nlm.nih.gov/PMC6273855
https://doaj.org/article/35a23aa2b7f44138a5f591745c60708f
Volume 21
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwEB1BOcAF8U2grIzECclq_J0eu0uXikOFWirtich2bHXVbYrIFmn76xnH2VUXEFzIIZFiR5rYL5438uQNwDspnFeh8TRaIankJlKnS0lj9KpiQSZQpWyLY310Jj_N1OxWqa-UE5blgfPA7QllubCWOxPRc4vKqqgwxJDKa0RrFdPqiz5vHUwNoRZDv5T3MAUG9XuXudRs6DDASaJDfMsL9WL9f2KYvyZK3vI800fwcKCM5CCb-hjuhPYJ3J-sK7U9ha-nqxZ5XDfviG0bMvm-Qsq3IKe9NOw1xtPkKpJxaG_ml_PG3qCVlNPledIoIh8QgT968e-OuBU5WFyscnYcOQn5n4fuGZxND79MjuhQN4F6uS-W1CgVg-cN08hJ0XY8uIi4nFSNdFZWkQtfMicZN3jVEYNEr6tSehFVIwITz2GnRRNeAmFJK0Y7Fpp9Jx1LZcmCLV00SFSQOpgCyvU41n4QFU-1LRY1Bhdp6Ovfhr6A95tHvmVFjb91HqfJ2XRMYtj9DYRIPUCk_hdECthdT209fKFdzUzaskS_LQp4u2nGiUsbJrYNV9epj0p5OLxEO15kJGws4RrXSqSbBZgtjGyZut3Szs97_W7dSwipV__j3V7DA5wHlRJsON-FHURWeIM0aelGcNfMDJ6r6ccR3BsfHn8-GfVfyU_oPRWH
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxEB6VcigXxJstBYwEF6RV16_dzQGhNiWktPRAW6knFttr06jppnRT0PZH8RsZ7wsCqLeeIsVONBl_Hn8Tz34D8FJwbaTNTegUF6FgiQt1HInQOSNTaoUHla-22IvHh-LDkTxagp_dszC-rLKLiXWgzmfG_0e-ThN_xYRxlr89-xb6rlH-drVrodHAYsdWPzBlK99sb-H6vmJs9O5gOA7brgKhEQM-DxMpnTUspzEythzPCGsZd7jZ0lxoJVLHuImoFpQl-Bo7TKFMnEbCcCdzbinH770BNwXnA7-j0tH7PsGjeBo2N6c4GK2fNg1ubYlplZc6YgtnX90i4H-89u_yzD_Ou9EduN0SVbLRIOsuLNniHqwMu_5w9-HzflUgeywnJVFFTobnFRLNKdmvBWkvMIsnM0c2bXE5OZ3k6hKtDFk4P_bKSGQLcf-9lhwvia7IxvSkamryyCfbPGlRPoDDa_HrQ1gu0ITHQKhXqIk1tflAC019MzSrIu0SpEdIWJIAos6PmWmlzH1HjWmGKY13ffaP6wN43X_krNHxuGrypl-cfqKX4K7fmJ1_zdodnXGpGFeK6cQhpeSpkk5i7ivwV2EYTV0Aa93SZm1cKLPfKA7gRT-MC-evaVRhZxd-jvTVPyxCOx41SOgtYTFGaCS5ASQLGFkwdXGkmBzXquFxLVwkV6826zmsjA8-7ma723s7T-AWelv64h3G1mAZ8WOfIgWb62c17gl8ue6N9gtObUep
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkYAL4s1CASPBBcna-JVkDwi1u6xaiipEqbQngu3YdMU2W5otKP1p_Dpm8tiygHrrKVLiRJPxzPibePINIS-UtE773LFgpGJKJIHZOFIsBKdT7hUaFVZb7MXbB-rdRE_WyK_uXxgsq-xiYh2o87nDb-R9nuAWE8RZ2Q9tWcSH0fjN8XeGHaRwp7Vrp9GYyK6vfkL6Vr7eGcFcvxRi_PbTcJu1HQaYUwO5YInWwTuR8xjQWw7rhfdCBnC8NFfWqDQI6SJuFRcJHOMA6ZSL00g5GXQuPZfw3CvkaiI1Rx9LJufJHoeVsdlFlXIQ9Y-aZre-hBQLaY_EyjpYtwv4H8b9u1Tzj7VvfIvcbEEr3Wys7DZZ88Udcn3Y9Yq7Sz7vVwUgyXJaUlPkdHhSAeic0f2anPYUMno6D3TLF2fTo2luzkBKJtjiEFmS6Ah84EdNP15SW9HN2beqqc-jH33z10V5jxxcil7vk_UCRHhIKEe2mthynw-sshwbo3kT2ZAAVALwkvRI1Okxcy2tOXbXmGWQ3qDqs39U3yOvlrccN5weFw3ewslZDkQ67vrE_ORr1np3JrUR0hhhkwDwUqZGBw15sIK3gpCahh7Z6KY2a2NEmZ1bdI88X16GicMtG1P4-SmO0VgJJCKQ40FjCUtJRAzRGgBvjyQrNrIi6uqVYnpYM4jHNYmRfnSxWM_INXCx7P3O3u5jcgOUrbGOR4gNsg7m458AGlvYp7XZU_Llsv3sNyyBS9Y
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+and+Crystal+Structures+of+Benzimidazole-2-thione+Derivatives+by+Alkylation+Reactions&rft.jtitle=Molecules+%28Basel%2C+Switzerland%29&rft.au=El+Ashry%2C+El+Sayed+H.&rft.au=El+Kilany%2C+Yeldez&rft.au=Nahas%2C+Nariman+M.&rft.au=Barakat%2C+Assem&rft.date=2015-12-22&rft.pub=MDPI&rft.eissn=1420-3049&rft.volume=21&rft.issue=1&rft_id=info:doi/10.3390%2Fmolecules21010012&rft_id=info%3Apmid%2F26703551&rft.externalDocID=PMC6273855
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1420-3049&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1420-3049&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1420-3049&client=summon