Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions

Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermo...

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Published inMolecules (Basel, Switzerland) Vol. 21; no. 1; pp. 12 - E12
Main Authors El Ashry, El, El Kilany, Yeldez, Nahas, Nariman, Barakat, Assem, Al-Qurashi, Nadia, Ghabbour, Hazem, Fun, Hoong-Kun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.12.2015
MDPI
Subjects
Alkylation
benzimidazole-thione
Benzimidazoles - chemical synthesis
Benzimidazoles - chemistry
Chemistry
Crystallography, X-Ray
Hydrogen Bonding
Models, Molecular
Molecular Structure
Potassium
Solvents
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
thiazino[3,2-a]benzimidazole
X-ray
Saudi Arabia
Riyadh Saudi Arabia
thiazino[3,2-a]benzimidazole
X-ray
benzimidazole-thione
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Summary:Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21010012