Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 7; p. 1519
• Main Authors: Parveen, Amna, Kim, Jin Hyun, Oh, Byeong Gyu, Subedi, Lalita, Khan, Zahra, Kim, Sun Yeou
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.06.2018; MDPI
• Subjects: advanced glycation end-products; aldose reductase; Animal models; Animals; Antidiabetics; Biological activity; Constituents; Diabetes; Diabetes mellitus; Diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - genetics; Diabetic Retinopathy - metabolism; Diabetic Retinopathy - pathology; Gene Expression Regulation - drug effects; Glycation End Products, Advanced - antagonists & inhibitors; Glycation End Products, Advanced - metabolism; Herbal medicine; Hexosamines - antagonists & inhibitors; Hexosamines - metabolism; Humans; Hypoglycemic Agents - isolation & purification; Hypoglycemic Agents - pharmacology; MAP kinase; Medicinal plants; metalloproteinase-9; mitogen-activated protein kinases; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; Oxidative Stress; Phytochemicals; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Phytotherapy - methods; Plant protection; Plants (botany); Plants, Medicinal - chemistry; poly (ADP-ribose) polymerase; Poly(ADP-ribose) Polymerases - genetics; Poly(ADP-ribose) Polymerases - metabolism; Protein kinase C; Protein Kinase C - genetics; Protein Kinase C - metabolism; reactive oxygen species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Retina - drug effects; Retina - metabolism; Retina - pathology; Retinopathy; Review; Scientific papers; Side effects; vascular endothelial growth factor; poly (ADP-ribose) polymerase; mitogen-activated protein kinases; vascular endothelial growth factor; reactive oxygen species; aldose reductase; phytochemicals; advanced glycation end-products; diabetic retinopathy; metalloproteinase-9; oxidative stress; protein kinase C
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23071519

: A variety of causative factors are involved in the initiation of diabetic retinopathy (DR). Current antidiabetic therapies are expensive and not easily accessible by the public. Furthermore, the use of multiple synthetic drugs leads to severe side effects, which worsen the diabetic patient’s condition. Medicinal plants and their derived phytochemicals are considered safe and effective treatment and their consumption can reduce the DR risk. In this article, we discuss a variety of medicinal plants, and their noteworthy bio-active constituents, that will be utilized as target based therapeutic strategies for DR. : A broad-spectrum study was conducted using published English works in various electronic databases including Science Direct, PubMed, Scopus, and Google Scholar. : Targeting the multiple pathological factors including ROS, AGEs formation, hexosamine flux, PARP, PKC, and MAPK activation through variety of bioactive constituents in medicinal plants, diabetes progression can be delayed with improved loss of vision. : Data reveals that traditional herbs and their prominent bioactive components control and normalize pathological cellular factors involved in DR progression. Therefore, studies should be carried out to explore the protective retinopathy effects of medicinal plants using experimental animal and humans models.