Synthesis of New Cisplatin Derivatives from Bile Acids

A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid mol...

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Published inMolecules (Basel, Switzerland) Vol. 25; no. 3; p. 655
Main Authors Seroka, Barbara, Łotowski, Zenon, Hryniewicka, Agnieszka, Rárová, Lucie, R Sicinski, Rafal, M Tomkiel, Aneta, W Morzycki, Jacek
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.02.2020
MDPI
Subjects
Aluminum
Apoptosis
Bile
Bile acids
Biocompatibility
Cancer
Chemistry
Chemotherapy
cholic acid
Cisplatin
Cytotoxicity
deoxycholic acid
Diamines
Drugs
hyodeoxycholic acid
Ligands
lithocholic acid
Membranes
Platinum
platinum(ii) complexes
Prostate
steroidal diamines
cholic acid
steroidal diamines
bile acids
deoxycholic acid
lithocholic acid
hyodeoxycholic acid
platinum(II) complexes
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Summary:A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Dedicated to Professor Hector F. DeLuca (University of Wisconsin Madison, USA) on the occasion of his 90th birthday.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25030655