Solidago graminifolia L. Salisb. ( Asteraceae ) as a Valuable Source of Bioactive Polyphenols: HPLC Profile, In Vitro Antioxidant and Antimicrobial Potential

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 14; p. 2666
• Main Authors: Toiu, Anca, Vlase, Laurian, Vodnar, Dan Cristian, Gheldiu, Ana-Maria, Oniga, Ilioara
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.07.2019; MDPI
• Subjects: Acids; Anti-Infective Agents - classification; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antibacterial activity; Antifungal activity; antimicrobial; Antimicrobial agents; antioxidant; Antioxidants; Antioxidants - classification; Antioxidants - isolation & purification; Antioxidants - pharmacology; Bioactive compounds; Biological activity; Biological properties; Biphenyl Compounds - antagonists & inhibitors; Cancer; Candida albicans - drug effects; Candida albicans - growth & development; Candida parapsilosis - drug effects; Candida parapsilosis - growth & development; Chloroform - chemistry; Chlorogenic acid; Chlorogenic Acid - isolation & purification; Chlorogenic Acid - pharmacology; Cytotoxicity; Dilution; Diuretics; Ethanol; Ethanol - chemistry; Flavonoids; Flavonoids - classification; Flavonoids - isolation & purification; Flavonoids - pharmacology; Fungicides; Herbal medicine; High-performance liquid chromatography; Inflammation; Liquid chromatography; Medicinal plants; Methanol - chemistry; Microbial Sensitivity Tests; Minimum inhibitory concentration; Obesity; Oils & fats; Phenolic compounds; Phenols; Phenols - classification; Phenols - isolation & purification; Phenols - pharmacology; Phytochemicals; Picrates - antagonists & inhibitors; Plant Components, Aerial - chemistry; Plant extracts; Plant Extracts - chemistry; polyphenolic compounds; Polyphenols; Quercetin - analogs & derivatives; Quercetin - isolation & purification; Quercetin - pharmacology; Solidago - chemistry; Solidago graminifolia; Solvents; Solvents - chemistry; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development; Wound healing; North America; Europe; antimicrobial; antioxidant; Solidago graminifolia; polyphenolic compounds
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24142666

species are often used in traditional medicine as anti-inflammatory, diuretic, wound-healing and antimicrobial agents. Still, the bioactive compounds and biological activities of some species have not been studied. The present work aimed to investigate the polyphenolic profile and the biological properties of L. Salisb., a poorly explored medicinal plant. The hydroalcoholic extracts from aerial parts were evaluated for total phenolic content (TPC), total flavonoid content (TFC) and the polyphenolic compounds were investigated by HPLC-MS. The antioxidant potential in vitro was determined using DPPH and FRAP assays. Antibacterial and antifungal effects were evaluated by dilution assays and MIC, MBC and MFC were calculated. The results showed that aerial parts contain an important amount of total phenolics (192.69 mg GAE/g) and flavonoids (151.41 mg RE/g), with chlorogenic acid and quercitrin as major constituents. The hydroalcoholic extracts showed promising antioxidant and antimicrobial potential, with potent antibacterial activity against and important antifungal effect against and . The obtained results indicated that the aerial parts of could be used as novel resource of phytochemicals in herbal preparations with antioxidant and antimicrobial activities.