Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 11; p. 1995
• Main Authors: Yang, Bing-You, Bi, Xue-Yan, Liu, Yan, Li, Guo-Yu, Yin, Xin, Kuang, Hai-Xue
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.11.2017; MDPI
• Subjects: Acids; Anemarrhena - chemistry; Asparagaceae; Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - pharmacology; Cancer; Chinese medicine; Chromatography; Cytotoxicity; disaccharide; Ethanol; Glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Hydrolysis; Hypertension; Ions; Laboratories; Magnetic Resonance Spectroscopy; Mass spectrometry; Mass spectroscopy; Molecular Structure; natural product; NMR; Nuclear magnetic resonance; Pharmacy; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; pyroglutamic acid; Rhizome - chemistry; Rhizomes; Scientific imaging; steroidal saponins; pyroglutamic acid; Asparagaceae; disaccharide; steroidal saponins; natural product; cytotoxicity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22111995

Four new compounds, aneglycoside A-C ( - ) and timosaponin U ( ), were isolated from the rhizomes of . Their structures were determined through extensive spectroscopic analysis, chemical characteristics, and high-resolution mass spectrometry (HRMS). All the isolations were evaluated for cytotoxicity against HepG2, Hela, and SGC7901 human cancer lines. Compounds , , and showed weak antiproliferative activities on HepG2, Hela, and SGC7901 cells.