Stimuli-Responsive Drug Delivery Systems for the Diagnosis and Therapy of Lung Cancer

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Numerous drugs have been developed to treat lung cancer patients in recent years, whereas most of these drugs have undesirable adverse effects due to nonspecific distribution in the body. To address th...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 3; p. 948
Main Authors Lin, Xu, Wu, Jiahe, Liu, Yupeng, Lin, Nengming, Hu, Jian, Zhang, Bo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.01.2022
MDPI
Subjects
Animals
Antineoplastic Agents - pharmacology
Cancer therapies
Chemotherapy
Delayed-Action Preparations - pharmacology
Drug Carriers - chemistry
drug delivery
Drug Delivery Systems
Drug therapy
Enzymes
Gold
Heat
Humans
Hydrogen-Ion Concentration
Immunotherapy
Lasers
Light
Lung cancer
Magnetic fields
Medical research
Monoclonal antibodies
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Neoplasms - drug therapy
Polymers
Review
Smart Materials - pharmacology
stimuli-responsive
Ultrasonic imaging
lung cancer
stimuli-responsive
drug delivery
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Summary:Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Numerous drugs have been developed to treat lung cancer patients in recent years, whereas most of these drugs have undesirable adverse effects due to nonspecific distribution in the body. To address this problem, stimuli-responsive drug delivery systems are imparted with unique characteristics and specifically deliver loaded drugs at lung cancer tissues on the basis of internal tumor microenvironment or external stimuli. This review summarized recent studies focusing on the smart carriers that could respond to light, ultrasound, pH, or enzyme, and provided a promising strategy for lung cancer therapy.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27030948