Parthenin—A Sesquiterpene Lactone with Multifaceted Biological Activities: Insights and Prospects

Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed Parthenium hysterophorus (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of th...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 17; p. 5347
Main Authors Kaur, Amarpreet, Kaur, Shalinder, Jandrotia, Rupali, Singh, Harminder, Batish, Daizy, Kohli, Ravinder, Rana, Virendra, Shakil, Najam
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 02.09.2021
MDPI
Subjects
Allelopathy
Asteraceae - chemistry
Asteraceae - metabolism
Cancer
Chemotherapy
Cytotoxicity
Enzymes
Leukemia
pharmacological properties
pseudoguaianolide
Review
sesquiterpene lactone
Sesquiterpenes - chemistry
Sesquiterpenes - metabolism
Sesquiterpenes - pharmacology
terpenoids
toxicology
toxicology
terpenoids
sesquiterpene lactone
pseudoguaianolide
pharmacological properties
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Summary:Parthenin, a sesquiterpene lactone of pseudoguaianolide type, is the representative secondary metabolite of the tropical weed Parthenium hysterophorus (Asteraceae). It accounts for a multitude of biological activities, including toxicity, allergenicity, allelopathy, and pharmacological aspects of the plant. Thus far, parthenin and its derivatives have been tested for chemotherapeutic abilities, medicinal properties, and herbicidal/pesticidal activities. However, due to the lack of toxicity–bioactivity relationship studies, the versatile properties of parthenin are relatively less utilised. The possibility of exploiting parthenin in different scientific fields (e.g., chemistry, medicine, and agriculture) makes it a subject of analytical discussion. The present review highlights the multifaceted uses of parthenin, on-going research, constraints in the practical applicability, and the possible workarounds for its successful utilisation. The main aim of this comprehensive discussion is to bring parthenin to the attention of researchers, pharmacologists, natural product chemists, and chemical biologists and to open the door for its multidimensional applications.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26175347