Transition Metal Complexes of Mixed Bioligands: Synthesis, Characterization, DFT Modeling, and Applications

Divalent transition metal complexes [MGlu-Arg (H2O)]H2O and [MGlu-Arg (H2O)]H2O, where M = Co, Ni, Cu, and Zn, Glu = glutamic acid, and Arg = L-arginine, are prepared and characterized using different techniques. DFT and TD-DFT modelling validated and interpreted some experimental results. Weight lo...

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Bibliographic Details
Published inJournal of chemistry Vol. 2019; no. 2019; pp. 1 - 18
Main Authors Abdel-Mottaleb, Mohamed Sabry, Hamed, E.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
Hindawi Limited
Wiley
Subjects
Adsorption
Aluminum
Aluminum compounds
Amino acids
Anticancer properties
Antimicrobial agents
Aqueous solutions
Arginine
Bacteria
Bacterial corrosion
Cancer
Chemical potential
Chemistry
Cobalt oxides
Coordination compounds
Copper
Copper oxides
Corrosion
Corrosion (Chemistry)
Corrosion inhibitors
Cytotoxicity
Dielectric properties
Glutamate
Glutamic acid
Hydrochloric acid
Laboratories
Ligands
Mathematical problems
Medical research
Metal oxides
Microscopy
Nanoparticles
Nickel
Nitrogen
Organic chemistry
Physics
Thermogravimetric analysis
Transition metal compounds
Weight loss
Cairo Egypt
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Summary:Divalent transition metal complexes [MGlu-Arg (H2O)]H2O and [MGlu-Arg (H2O)]H2O, where M = Co, Ni, Cu, and Zn, Glu = glutamic acid, and Arg = L-arginine, are prepared and characterized using different techniques. DFT and TD-DFT modelling validated and interpreted some experimental results. Weight loss technique reveals efficient corrosion inhibition action of these complexes towards aluminum metal at different temperatures. Our results point to corrosion inhibition through chemical adsorption on the aluminum surface. Additionally, a facile calcination of Co and Cu complexes at 550°C yields nanosized oxides of Co3O4, CoO, and CuO crystalline phases. The complexes show remarkable biological activities towards pathogenic bacteria and fungi. Moreover, in vitro anticancer activity evaluation of these complexes is achieved against hepatocellular carcinoma (HepG-2). The results are correlated with molecular descriptors such as chemical potential and hardness obtained from the frontier orbitals.
ISSN:2090-9063
2090-9071
DOI:10.1155/2019/3241061