New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 11; p. 2873
• Main Authors: Yan, Wei, Cao, Ling-Ling, Zhang, Yang-Yang, Zhao, Ran, Zhao, Shuang-Shuang, Khan, Babar, Ye, Yong-Hao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.11.2018; MDPI
• Subjects: Antifungal activity; Biomedical materials; Carbendazim; Chaetomium globosum; Chromatography; Circular dichroism; Dichroism; Endophytes; Fungi; Fungicides; Hydrocarbons; In vivo methods and tests; indole alkaloid; Ionization; isocoumarin derivatives; Mass spectrometry; Mass spectroscopy; Metabolites; Natural products; NMR; Nuclear magnetic resonance; Pesticides; Plant diseases; Rot; Scientific imaging; United States > US; China; indole alkaloid; Chaetomium globosum; antifungal activity; isocoumarin derivatives
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules23112873

Five metabolites including two new ones, prochaetoviridin A ( ) and chaetoindolin A ( ), were isolated from the endophytic fungus CDW7. Compounds and were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds ⁻ were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A ( ) exhibited antifungal activity against with an EC value of 1.97 μg/mL. In vivo test showed that displayed a protective efficacy of 64.3% against rape rot at the dosage of 200 μg/mL, comparable to that of carbendazim (69.2%).