Endometriosis does not seem to be an influencing factor of hypertensive disorders of pregnancy in IVF / ICSI cycles

• Published in: Reproductive biology and endocrinology Vol. 20; no. 1; pp. 57 - 10
• Main Authors: Lee, Pingyin, Zhou, Canquan, Li, Yubin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.03.2022; BioMed Central; BMC
• Subjects: Birth weight; Cardiovascular disease; Corpus luteum; Cryopreservation; Diabetes; Embryo transfer; Embryos; Endometriosis; Fertilization in vitro; Frozen-thawed embryo transfer; Hypertension; Hypertensive disorders of pregnancy; Immune system; In vitro fertilization; Infertility; Inflammation; Laparoscopy; Morphology; Neonates; Ovaries; Ovulation; Patients; Preeclampsia; Pregnancy; Pregnancy complications; Pregnant women; Reproductive technologies; Thyroid gland; Ultrasonic imaging; Vitrification; Womens health; United Kingdom; Istanbul Turkey; Switzerland; Turkey; In vitro fertilization; Endometriosis; Frozen-thawed embryo transfer; Hypertensive disorders of pregnancy
• ISSN: 1477-7827; 1477-7827
• DOI: 10.1186/s12958-022-00922-5

To evaluate whether the incidence of hypertensive disorders of pregnancy (HDP) in pregnant women was related to endometriosis (EM), ovulation and embryo vitrification technology. A retrospective cohort study was conducted on the clinical data of 3674 women who were treated with IVF / ICSI in the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-sen University and maintained clinical pregnancy for more than 20 weeks. All pregnancies were followed up until the end of pregnancy. The follow-up consisted of recording the course of pregnancy, pregnancy complications, and basic situation of newborns. Compared with NC-FET without EM, HRT-FET without EM was found to have a higher incidence of HDP during pregnancy (2.7% V.S. 6.1%, P<0.001); however, no significant difference was found in the incidence of HDP between NC-FET and HRT-FET combined with EM (4.0% V.S. 5.7%, P>0.05). In total frozen-thawed embryo transfer (total-FET), the incidence of HDP in the HRT cycle without ovulation (HRT-FET) was observed to be higher than that in the NC cycle with ovulation (NC-FET) (2.8% V.S. 6.1%, P<0.001). In patients with EM, no significant difference was found in the incidence of HDP between fresh ET and NC-FET (1.2% V.S. 4.0%, P>0.05). EM does not seem to have an effect on the occurrence of HDP in assisted reproductive technology. During the FET cycle, the formation of the corpus luteum may play a protective role in the occurrence and development of HDP. Potential damage to the embryo caused by cryopreservation seems to have no effect on the occurrence of HDP.