Biflavonoids from Selaginella doederleinii as Potential Antitumor Agents for Intervention of Non-Small Cell Lung Cancer
Four new biflavonoids ( - ) were isolated from together with a known biflavonoid derivative ( ). Their structures contained a rare linker of individual flavones to each other by direct C-3-O-C-4''' bonds, and were elucidated by extensive spectroscopic data, including HRESIMS, NMR and...
Saved in:
Published in | Molecules (Basel, Switzerland) Vol. 26; no. 17; p. 5401 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
05.09.2021
MDPI |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Four new biflavonoids (
-
) were isolated from
together with a known biflavonoid derivative (
). Their structures contained a rare linker of individual flavones to each other by direct C-3-O-C-4''' bonds, and were elucidated by extensive spectroscopic data, including HRESIMS, NMR and ECD data. All isolates significantly inhibited the proliferation of NSCLC cells (IC
= 2.3-8.4 μM) with low toxicity to non-cancer MRC-5 cells, superior to the clinically used drug DDP. Furthermore, the most active compound
suppressed XIAP and survivin expression, promoted upregulation of caspase-3/cleaved-caspase-3, as well as induced cell apoptosis and cycle arrest in A549 cells. Together, our findings suggest that
may be worth studying further for intervention of NSCLC. |
---|---|
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules26175401 |