Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 18; p. 3334
• Main Authors: Tartaglia, Angela, Kabir, Abuzar, Ulusoy, Songul, Ulusoy, Halil Ibrahim, Merone, Giuseppe Maria, Savini, Fabio, D'Ovidio, Cristian, de Grazia, Ugo, Gabrielli, Serena, Maroni, Fabio, Bruni, Pantaleone, Croce, Fausto, Melucci, Dora, Furton, Kenneth G, Locatelli, Marcello
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.09.2019; MDPI
• Subjects: biological matrix; Cartridges; Cosmetics; extraction procedure; High performance liquid chromatography; HPLC-PDA; Humans; Imprinted polymers; Liquid chromatography; MIPs; Molecular Imprinting; parabens; Parabens - chemistry; Photodiodes; Polymerization; Polymers; Polymers - chemical synthesis; Polymers - chemistry; Retention; Selectivity; Sol-gel processes; Solid Phase Extraction; Solid phases; Sorbents; stationary phase characterization; Urine - chemistry; United States > US; HPLC-PDA; MIPs; stationary phase characterization; parabens; biological matrix; extraction procedure
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24183334

In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The imprinted polymers were created using sol-gel molecular imprinting process. All the seven parabens were considered herein in order to check the phase selectivity. By means of a validated HPLC-photodiode array detector (PDA) method all seven parabens were resolved in a single chromatographic run of 25 min. These SPE sorbents, packed in SPE empty cartridges, were first characterized in terms of extraction capability, breakthrough volume, retention volume, hold-up volume, number of theoretical plates, and retention factor. Finally, the device was applied to a real urine sample to check the method feasibility on a very complex matrix. The new paraben imprinted SPE sorbents, not yet present in the literature, potentially encourage the development of novel molecularly imprinted polymers (MIPs) to enhance the extraction efficiency, and consequently the overall analytical performances, when the trace quantification is required.