Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 3; p. 652
• Main Authors: Avila, Yelixza I, Chandler, Morgan, Cedrone, Edward, Newton, Hannah S, Richardson, Melina, Xu, Jie, Clogston, Jeffrey D, Liptrott, Neill J, Afonin, Kirill A, Dobrovolskaia, Marina A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.01.2021; MDPI
• Subjects: Cancer; Cell Line, Tumor; Cytokines; Cytokines - metabolism; Dendrimers; Deoxyribonucleic acid; DNA; Drug Carriers - chemistry; Drug Delivery Systems - methods; Humans; immunology; Immunostimulation; immunotherapies; Lipids; Lipids - chemistry; Microscopy; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; NANPs; nucleic acid nanoparticles; Nucleic acids; Nucleic Acids - administration & dosage; Nucleic Acids - chemistry; vaccines; immunotherapies; cytokines; nucleic acid nanoparticles; vaccines; immunology; NANPs
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules26030652

Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.