Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines

As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a strain, which is associated with the plant Schott. FUS showed rapid and sub-micromolar IC against pancreatic cancer cell lines. Time-dependent survival analysis and microsc...

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Published inMolecules (Basel, Switzerland) Vol. 23; no. 12; p. 3288
Main Authors Hoque, Nazia, Hasan, Choudhury Mahmood, Rana, Md Sohel, Varsha, Amrit, Sohrab, Md Hossain, Rahman, Khondaker Miraz
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.12.2018
MDPI
Subjects
Breast cancer
cytotoxic activity
Cytotoxicity
Endophytes
endophytic fungi
Fungi
Fusaproliferin
Investigations
Metastasis
Morphology
Mycotoxins
Pancreatic cancer
Pharmaceutical sciences
sesterterpene
Survival analysis
Toxicity
Tumor cell lines
Bangladesh
Germany
pancreatic cancer
cytotoxic activity
endophytic fungi
sesterterpene
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Summary:As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a strain, which is associated with the plant Schott. FUS showed rapid and sub-micromolar IC against pancreatic cancer cell lines. Time-dependent survival analysis and microscopy imaging showed rapid morphological changes in cancer cell lines 4 h after incubation with FUS. This provides a new chemical scaffold that can be further developed to obtain more potent synthetic agents against pancreatic cancer.
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content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23123288