Glial activation and midkine and pleiotrophin transcription in the ventral tegmental area are modulated by morphine administration

Abstract Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and plei...

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Published inJournal of neuroimmunology Vol. 274; no. 1; pp. 244 - 248
Main Authors García-Pérez, Daniel, Luisa Laorden, M, Núñez, Cristina, Victoria Milanés, M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.09.2014
Subjects
Allergy and Immunology
Analgesics, Opioid - pharmacology
Animals
Carrier Proteins - genetics
Carrier Proteins - immunology
Cytokines - genetics
Cytokines - immunology
Glial fibrillary acidic protein
Glial Fibrillary Acidic Protein - metabolism
Male
Midkine
Morphine - pharmacology
Morphine Dependence - genetics
Morphine Dependence - immunology
Nerve Growth Factors - genetics
Nerve Growth Factors - immunology
Neuroglia - immunology
Neurology
Opiate dependence
Pleiotrophin
Rats
Rats, Wistar
Reward pathway
Transcription, Genetic - immunology
Ventral Tegmental Area - drug effects
Ventral Tegmental Area - immunology
VTA
BDNF
Glial fibrillary acidic protein
Pleiotrophin
PTN
GFAP-IR
GFAP
Nucleus accumbens
NAc
Brain-derived neurotrophic factor
Opiate dependence
Reward pathway
Midkine
Ventral tegmental area
MK
GFAP-immunoreactivity
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Summary:Abstract Opiates cause persistent restructuring in the mesolimbic reward system. Although a possible role for midkine and pleiotrophin cytokines in the field of synaptic plasticity has been proposed, it has not been assessed whether morphine administration regulates astrogliosis and midkine and pleiotrophin transcription. We observed that single morphine injection and chronic morphine increased glial fibrillary acidic protein expression in the ventral tegmental area (VTA). Interestingly, single morphine injection and chronic morphine increased VTA midkine and pleiotrophin mRNA expression. Given these results, we hypothesize a role for these cytokines in mediating, at least in part, acute neuroprotective effects and chronic neurotrophic adaptations that contribute to drug dependence.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2014.07.017