Polygonum capitatum , the Hmong Medicinal Flora: A Comprehensive Review of Its Phytochemical, Pharmacological and Pharmacokinetic Characteristics

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 19; p. 6407
• Main Authors: Lin, Yan, He, Lei, Chen, Xing-Jun, Zhang, Xu, Yan, Xue-Long, Tu, Bo, Zeng, Zhu, He, Ming-Hui
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.09.2022; MDPI
• Subjects: Acids; Analgesics; Anti-Inflammatory Agents - pharmacology; Antiinfectives and antibacterials; Antioxidants - therapeutic use; Aquatic plants; Botany; chemical analysis; Diuretics; Ethnopharmacology; FDA approval; Flavonoids; Flavonoids - analysis; Herbal medicine; Herbs; Humans; Inflammation; Medicinal plants; Medicine; Pharmacokinetics; pharmacological activities; Pharmacology; Phenols; Phytochemicals; Phytochemicals - pharmacology; Plant Extracts - chemistry; Plants, Medicinal - chemistry; Polygonum - chemistry; Polygonum capitatum; Pyelonephritis; Qualitative analysis; Review; Urinary tract; China; pharmacological activities; Polygonum capitatum; flavonoids; chemical analysis
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27196407

, known as "Tou Hua Liao" (Chinese name), is a crucial source of Hmong medicinal plants that has benefited human health for a long time. This folk-medicinal plant is widely distributed in the south-west of China for the treatment of various urologic disorders including urinary tract infections, pyelonephritis, and urinary calculus. The purpose of this paper was to provide a systematic and comprehensive overview of the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics and clinical applications of this flora. Up until the end of 2022, at least 91 compounds had been reported from , mainly covering the classes of flavonoids, lignanoids, phenols and other components. The compounds and extracts isolated from exhibit a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, anticancer, analgesic, hypothermic, diuretic and other pharmacological effects. Qualitative and quantitative chemical analyses were also covered. Furthermore, the possible development trends and perspectives for future research on this medicinal plant were also discussed.