Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal c...

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Published inMolecules (Basel, Switzerland) Vol. 18; no. 6; pp. 6584 - 6596
Main Authors Guo, Yuh-Cherng, Chang, Che-Mai, Hsu, Wen-Li, Chiu, Siou-Jin, Tsai, Yao-Ting, Chou, Yii-Her, Hou, Ming-Feng, Wang, Jaw-Yan, Lee, Mei-Hsien, Tsai, Ke-Li, Chang, Wei-Chiao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.06.2013
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Summary:Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.
Bibliography:These authors contribute equally to this paper.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18066584