Regulation of DNA repair by ubiquitylation

• Published in: Biochemistry (Moscow) Vol. 76; no. 1; pp. 69 - 79
• Main Authors: Dianov, G. L, Meisenberg, C, Parsons, J. L
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 2011; SP MAIK Nauka/Interperiodica; Springer; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cancer; Deoxyribonucleic acid; DNA; DNA Damage; DNA Repair; Genetic aspects; Genomes; Glycosylation; Humans; Ionizing radiation; Life Sciences; Microbiology; Mutagens; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - therapy; Nuclear radiation; Post-translational modification; Prevention; Proteins; Review; Ubiquitin; Ubiquitination; post-translational protein modification; ubiquitylation; regulation of DNA repair systems; DNA repair pathways
• ISSN: 0006-2979; 1608-3040
• DOI: 10.1134/S0006297911010093

Cellular DNA repair is a frontline system that is responsible for maintaining genome integrity and thus preventing premature aging and cancer by repairing DNA lesions and strand breaks caused by endogenous and exogenous mutagens. However, it is also the principal cellular system in cancer cells that counteracts the killing effect of the major cancer treatments, e.g. chemotherapy and ionizing radiation. Although it is clear that an individual's DNA repair capacity varies, the mechanisms involved in the regulation of repair systems that are responsible for such variations are only just emerging. This knowledge gap is impeding the finding of new cancer therapy targets and the development of novel treatment strategies. In recent years the vital role of post-translational modifications of DNA repair proteins, including ubiquitylation and phosphorylation, has been uncovered. This review will cover recent progress in our understanding of the role of ubiquitylation in the regulation of DNA repair.