Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb

• Published in: Molecules (Basel, Switzerland) Vol. 18; no. 8; pp. 8752 - 8763
• Main Authors: Huang, Hui-Chi, Lin, Ming-Kuem, Hwang, Syh-Yuan, Hwang, Tsong-Long, Kuo, Yao-Haur, Chang, Chi-I, Ou, Chung-Yi, Kuo, Yueh-Hsiung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.07.2013; MDPI
• Subjects: Agavaceae; anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Carbon; Cells, Cultured; Cytotoxicity; Dracaena - chemistry; Dracaena angustifolia Roxb; drangustosides A–B; Humans; Inflammatory diseases; Magnetic Resonance Spectroscopy; Medicine; Molecular Structure; Natural products; Neutrophils; Neutrophils - drug effects; Pancreatic Elastase - antagonists & inhibitors; Pancreatic Elastase - chemistry; Phytochemicals; Plant Extracts - chemistry; Plant Extracts - pharmacology; Saponins - chemistry; Saponins - pharmacology; steroidal saponins; Steroids - chemistry; Steroids - pharmacology; Superoxides - chemistry; China; Taiwan

Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and...