Two Anti-inflammatory Steroidal Saponins from Dracaena angustifolia Roxb

Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and...

Full description

Saved in:
Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 18; no. 8; pp. 8752 - 8763
Main Authors Huang, Hui-Chi, Lin, Ming-Kuem, Hwang, Syh-Yuan, Hwang, Tsong-Long, Kuo, Yao-Haur, Chang, Chi-I, Ou, Chung-Yi, Kuo, Yueh-Hsiung
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.07.2013
MDPI
Subjects
Agavaceae
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Carbon
Cells, Cultured
Cytotoxicity
Dracaena - chemistry
Dracaena angustifolia Roxb
drangustosides A–B
Humans
Inflammatory diseases
Magnetic Resonance Spectroscopy
Medicine
Molecular Structure
Natural products
Neutrophils
Neutrophils - drug effects
Pancreatic Elastase - antagonists & inhibitors
Pancreatic Elastase - chemistry
Phytochemicals
Plant Extracts - chemistry
Plant Extracts - pharmacology
Saponins - chemistry
Saponins - pharmacology
steroidal saponins
Steroids - chemistry
Steroids - pharmacology
Superoxides - chemistry
China
Taiwan
Online AccessGet full text

Cover

More Information
Summary:Two new steroidal saponins, named drangustosides A–B (1–2), together with eight known compounds 3–10 were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18088752