Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts
A new abietane diterpene namely plectrabarbene ( ), together with two known compounds: sugiol ( ) and 11,14-dihydroxy-8,11,13-abietatrien-7-one ( ) have been isolated from the aerial parts of Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV...
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Published in | Molecules (Basel, Switzerland) Vol. 25; no. 10; p. 2365 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
20.05.2020
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | A new abietane diterpene namely plectrabarbene (
), together with two known compounds: sugiol (
) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (
) have been isolated from the aerial parts of
Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (
-
) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules25102365 |