Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis

• Published in: Annals of Saudi medicine Vol. 37; no. 2; pp. 99 - 105
• Main Authors: Xu, Mingzhu, Xu, Jialiang, Yang, Xiangjun
• Format: Journal Article
• Language: English
• Published: Saudi Arabia KING FAISAL SPECIALIST HOSPITAL & RESEARCH CENTRE 01.03.2017; King Faisal Specialist Hospital and Research Centre
• Subjects: Age; Alcohol; Arteriosclerosis; Asthma; Asthma - complications; Cardiovascular disease; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Confidence intervals; Coronary vessels; Diabetes; Epidemiology; Female; Health risk assessment; Humans; Incidence; Linear Models; Male; Meta-analysis; Mortality; Quality; Review; Risk Factors; Sex Factors; Stroke; Studies; United States > US
• ISSN: 0256-4947; 0975-4466
• DOI: 10.5144/0256-4947.2017.99

Previous studies have demonstrated that asthma might be associated with an increase in cardiovascular disease (CVD) and death. However, this relationship differs by gender. To systematically evaluate the association of asthma on the incidence of CVD and death in cohort studies. Fixed and random effects models were used to calculate risk estimates in a meta-analysis. Potential publication bias was calculated using a funnel plot, Begg's rank correlation test, and Egger's linear regression test. We searched the PubMed and Embase databases for studies that examined the relationship between asthma and CVD or all-cause mortality. Prospective and retrospective cohort studies. Ten studies containing 406 426 participants were included. The summary relative risk (95% confi-dence interval, CI) for patients with asthma was 1.33 (95% CI: 1.15-1.53), for CVD in women, it was 1.55 (95% CI: 1.20-2.00), for CVD in men it was 1.20 (95% CI: 0.92-1.56), and for all-cause mortality in both genders it was 1.36 (95% CI: 1.01-1.83). These findings remained consistent after sensitivity analysis. The results indicate that asthma was associated with an increased risk of CVD and all-cause mortality. Systematic review was not registered.