Placental deposition of C-reactive protein is a common feature of human pregnancy

• Published in: Placenta (Eastbourne) Vol. 36; no. 6; pp. 704 - 707
• Main Authors: Kim, E.N, Yoon, B.H, Jeon, E.J, Lee, J.B, Hong, J.-S, Lee, J.Y, Hwang, D, Kim, K.C, Kim, J.-S, Kim, C.J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2015
• Subjects: Abortion, Spontaneous - metabolism; Animals; C-reactive protein; C-Reactive Protein - metabolism; Female; Humans; Immunohistochemistry; Internal Medicine; Mice; Obstetric Labor, Premature - metabolism; Obstetrics and Gynecology; Placenta; Placenta - metabolism; Pre-Eclampsia - metabolism; Pregnancy; Trophoblast; Trophoblasts - metabolism; Immunohistochemistry; CRP; C-reactive protein; isolated preeclampsia; mCRP; maternal vascular underperfusion; acute chorioamnionitis; Trophoblast; spontaneous preterm delivery; MVU; FGR; TD; Placenta; monomeric C-reactive protein; fetal growth restriction; fetal vascular thrombo-occlusive disease; sPTD; chronic placental inflammation; FVTOD; term delivery; CPI; ACA; iPE
• ISSN: 0143-4004; 1532-3102
• DOI: 10.1016/j.placenta.2015.03.006

Abstract This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.