Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

Magnesium (Mg ) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully charact...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 9; p. 2419
Main Authors Case, Derek R, Zubieta, Jon, Gonzalez, Ren, Doyle, Robert P
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.04.2021
MDPI
Subjects
amino acid chelate
Bioavailability
CaCo-2 cells
Chelates
Chelation
Glycine
Hydration
Hypomagnesemia
Ligands
Magnesium
NMR
Nuclear magnetic resonance
Solubility
triglycine
amino acid chelate
magnesium
solubility
CaCo-2 cells
triglycine
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Summary:Magnesium (Mg ) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG ), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG ), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26092419