Cholinergic Chemotransmission and Anesthetic Drug Effects at the Carotid Bodies

General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral che...

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Published inMolecules (Basel, Switzerland) Vol. 25; no. 24; p. 5974
Main Authors Honing, Maarten, Martini, Chris, van Velzen, Monique, Niesters, Marieke, Dahan, Albert, Boon, Martijn
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.12.2020
MDPI
Subjects
Acidosis
Analgesics
Anesthesia
Carbon dioxide
Chemoreception (internal)
cholinergic transmission
Cholinergics
Experiments
Hypnotics
Hypoxia
Mammals
Muscle contraction
Muscle relaxants
Muscles
Nervous system
Neurotransmitters
Pain
peripheral chemosensitivity
Permeability
Review
Signal transduction
peripheral chemosensitivity
cholinergic transmission
muscle relaxants
anesthesia
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Summary:General anesthesia is obtained by administration of potent hypnotics, analgesics and muscle relaxants. Apart from their intended effects (loss of consciousness, pain relief and muscle relaxation), these agents profoundly affect the control of breathing, in part by an effect within the peripheral chemoreflex loop that originates at the carotid bodies. This review assesses the role of cholinergic chemotransmission in the peripheral chemoreflex loop and the mechanisms through which muscle relaxants and hypnotics interfere with peripheral chemosensitivity. Additionally, consequences for clinical practice are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25245974