Altered Intrinsic Regional Spontaneous Brain Activity in Patients With Severe Obesity and Meibomian Gland Dysfunction: A Resting-State Functional Magnetic Resonance Imaging Study

• Published in: Frontiers in human neuroscience Vol. 16; p. 879513
• Main Authors: Liu, Yi, Tan, Sheng-Xing, Wu, Yu-Kang, Shen, Yan-Kun, Zhang, Li-Juan, Kang, Min, Ying, Ping, Pan, Yi-Cong, Shu, Hui-Ye, Shao, Yi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 19.05.2022; Frontiers Media S.A
• Subjects: Alzheimer's disease; Angiography; Behavior; Body mass index; Brain mapping; Cerebellum; Cerebrum; Confocal microscopy; Cornea; Correlation analysis; Data analysis; Diabetes; Frontal gyrus; Functional magnetic resonance imaging; Hospital Anxiety Depression Scale; Lipids; Magnetic resonance imaging; meibomian gland dysfunction; Neuroimaging; Neuroscience; Obesity; Patients; regional homogeneity; resting state; severe obesity; Software; Temporal gyrus; Thalamus; Time series; Values; Beijing China; United States > US; China; resting state; Hospital Anxiety Depression Scale; meibomian gland dysfunction; regional homogeneity; severe obesity; functional magnetic resonance imaging
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2022.879513

To evaluate potential regional homogeneity (ReHo) cerebrum function lesions in people with severe obesity and meibomian gland dysfunction (SM) and probe the connection between aberrant cerebrum activity and clinical manifestations. An aggregation of 12 patients with SM, and 12 healthy controls (HCs) closely matched in age and gender were enrolled. We applied corneal confocal microscopy and fundus angiography to compare imaging distinctions between the two groups. SMs were required to carefully fill out the Hospital Anxiety Depression Scale (HADS) forms, and a correlation analysis was performed. ReHo was also utilized to appraise partial differences in spontaneous cerebrum function. Receiver operating characteristic (ROC) curves were created to partition ReHo values between patients with SM and the HCs. ReHo values for the left cerebellum (LC), right fusiform gyrus (RFG), left inferior temporal gyrus (LITG), left rectus gyrus (LRG), right thalamus (RT), right caudate (RC), left insula (LI), and left thalamus (LT) of subjects with SM were notably higher than those of the HCs ( < 0.05). ReHo values of the right middle frontal gyrus (RMFG) in subjects with SM were decreased notably compared to the HCs ( < 0.05). ReHo values for the RMFG showed a negative correlation with the anxiety scores (ASs; = -0.961, < 0.001) and ReHo values for the RFG showed a positive correlation with the depression scores (DSs; = 0.676, = 0.016). The areas under the ROC curve were 1.000 ( < 0.001) for the RMFG, LC, LITG, LRG, RC, LI, and LT and 0.993 ( < 0.001) for the RFG and RT. The results from the ROC curve analysis indicated that changes in the ReHo values of some brain regions may help diagnose SM. Our research emphasized that patients with SM had lesions in synchronized neural activity in many encephalic areas. Our discoveries may provide beneficial information for exploring the neuromechanics of SM.