MHC Class II Tetramers

MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic d...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 188; no. 6; pp. 2477 - 2482
Main Author Nepom, Gerald T
Format Journal Article
LanguageEnglish
Published England 15.03.2012
Subjects
Animals
CD4-Positive T-Lymphocytes - cytology
Epitopes - immunology
Flow Cytometry - methods
Histocompatibility Antigens Class II - chemistry
Histocompatibility Antigens Class II - immunology
Humans
Immunophenotyping - methods
Protein Multimerization
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Summary:MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic diversity of potential class II restriction elements, require targeted experimental design. Translational opportunities for immune disease monitoring are driving the rapid development of HLA class II tetramer use in clinical applications, together with innovations in tetramer production and epitope discovery.
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ISSN:0022-1767
1550-6606
1550-6606
DOI:10.4049/jimmunol.1102398