Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review

Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by Sertoli cells. Melatonin acts as a local modulator of the...

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Published inMolecules (Basel, Switzerland) Vol. 23; no. 2; p. 447
Main Authors Yu, Kun, Deng, Shou-Long, Sun, Tie-Cheng, Li, Yuan-Yuan, Liu, Yi-Xun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.02.2018
MDPI
Subjects
Leydig cell
Melatonin
Review
Sertoli cell
steroidogenesis
steroidogenesis
Sertoli cell
melatonin
Leydig cell
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Summary:Melatonin is a ubiquitous molecule and exhibits different effects in long-day and short-day breeding animals. Testosterone, the main resource of androgens in the testis, is produced by Leydig cells but regulated mainly by cytokine secreted by Sertoli cells. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular proliferation and energy metabolism and, consequently, can regulate steroidogenesis. These suggest melatonin as a key player in the regulation of steroidogenesis. However, the melatonin-induced regulation of steroid hormones may differ among species, and the literature data indicate that melatonin has important effects on steroidogenesis and male reproduction.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23020447