Silence of the Genes

A major challenge in present day biology is to decipher the molecular function of the unknown genes. Algorithms are being developed to predict effective siRNA sequences for efficient screening of large numbers of genes but have not yet been validated.

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 101; no. 15; pp. 5313 - 5314
Main Authors Singer, Oded, Yanai, Amiel, Verma, Inder M.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 13.04.2004
National Acad Sciences
Subjects
Algorithms
Animals
Cell lines
Cells
Commentaries
DNA
Gene Library
Gene Silencing
Genes
Genetic Techniques
Genetic vectors
Genetics
Humans
Libraries
Messenger RNA
Nucleic Acid Conformation
Phenotypes
Promoter Regions, Genetic
Ribonucleic acid
RNA
RNA Polymerase III - genetics
RNA, Small Interfering - chemistry
RNA, Small Interfering - genetics
Small interfering RNA
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Summary:A major challenge in present day biology is to decipher the molecular function of the unknown genes. Algorithms are being developed to predict effective siRNA sequences for efficient screening of large numbers of genes but have not yet been validated.
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E-mail: verma@salk.edu.
See companion article on page 5494.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0401209101