In vitro study of oxytetracycline adsorption on activated charcoal

• Published in: Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes Vol. 35; no. 5; pp. 559 - 569
• Main Authors: Alegakis, A. K., Tzatzarakis, M. N., Tsatsakis, A. M., Vlachonikolis, I. G., Liakou, V.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.09.2000; Taylor & Francis
• Subjects: activated charcoal; Adsorption; adsorption capacity; Animal productions; Biological and medical sciences; Charcoal - chemistry; Environmental Pollutants; Fundamental and applied biological sciences. Psychology; General pharmacology; Hydrogen-Ion Concentration; In vitro; Medical sciences; Models, Chemical; oxytetracycline; Oxytetracycline - chemistry; Oxytetracycline - pharmacokinetics; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Terrestrial animal productions; Vertebrates; Oxytetracycline; Stomach; Adsorption; Activated carbon; Treatment efficiency; Freundlich isotherm; pH; Pharmaceutical care; Animal production; In vitro
• ISSN: 0360-1234; 1532-4109
• DOI: 10.1080/03601230009373292

In vitro adsorption experiments simulating pH in gastric environment and using Langmuir isotherm, showed that 408 mg of oxytetracycline was adsorbed per gram of activated charcoal. Langmuir isotherm fitted adsorption data better than a Freundlich isotherm. Freundlich isotherm showed a specific adsorption capacity of 518 mg/g for activated charcoal. Both isotherm parameters indicated a strong oxytetracycline adsorption on activated charcoal in terms of quantity and binding strength. The results demonstrate that the concomitant use of oxytetracyline and activated charcoal should be avoided.