A Characterization of the Electrophysiological and Morphological Properties of Vasoactive Intestinal Peptide (VIP) Interneurons in the Medial Entorhinal Cortex (MEC)

Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their activation. Cortical Vasoactive Intestinal Pepti...

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Published inFrontiers in neural circuits Vol. 15; p. 653116
Main Authors Badrinarayanan, Saishree, Manseau, Frédéric, Williams, Sylvain, Brandon, Mark P.
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 23.07.2021
Frontiers Media S.A
Subjects
Action Potentials
Animals
characterization
Cortex (entorhinal)
Entorhinal Cortex
in vitro patch clamp
Interneurons
Interneurons - metabolism
Intestine
Laboratories
medial entorhinal cortex
Mice
Morphology
Neuroscience
Patch-Clamp Techniques
Peptides
Sucrose
Vasoactive agents
Vasoactive intestinal peptide
Vasoactive Intestinal Peptide - metabolism
VIP interneurons
Canada
United States > US
Germany
VIP interneurons
medial entorhinal cortex
characterization
in vitro patch clamp
interneurons
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Summary:Circuit interactions within the medial entorhinal cortex (MEC) translate movement into a coherent code for spatial location. Entorhinal principal cells are subject to strong lateral inhibition, suggesting that a disinhibitory mechanism may drive their activation. Cortical Vasoactive Intestinal Peptide (VIP) expressing inhibitory neurons are known to contact other interneurons and excitatory cells and are thus capable of providing a local disinhibitory mechanism, yet little is known about this cell type in the MEC. To investigate the electrophysiological and morphological properties of VIP cells in the MEC, we use in vitro whole-cell patch-clamp recordings in VIPcre/tdTom mice. We report several gradients in electrophysiological properties of VIP cells that differ across laminae and along the dorsal-ventral MEC axis. We additionally show that VIP cells have distinct morphological features across laminae. Together, these results characterize the cellular and morphological properties of VIP cells in the MEC.
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Reviewed by: Jochen Ferdinand Staiger, University of Göttingen, Germany; Lisa Topolnik, Laval University, Canada
Edited by: Maximiliano Jose Nigro, Norwegian University of Science and Technology, Norway
ISSN:1662-5110
1662-5110
DOI:10.3389/fncir.2021.653116