Bioactive phenylpropanoid glycosides from Tabebuia avellanedae

Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison wit...

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Published inMolecules (Basel, Switzerland) Vol. 18; no. 7; pp. 7336 - 7345
Main Authors Suo, Maorong, Ohta, Tomihisa, Takano, Fumihide, Jin, Shouwen
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.06.2013
MDPI
Subjects
antioxidant activity
Antioxidants
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Cytochrome P-450 CYP3A Inhibitors
Enzymes
Free Radical Scavengers - chemistry
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
phenylpropanoid glycosides
Plant Bark - chemistry
Plant Extracts - chemistry
Propanols - chemistry
Propanols - isolation & purification
Tabebuia - chemistry
Tabebuia avellanedae Lorentz ex Griseb
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Summary:Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, and compound 5 give the highest antioxidant activity among all compounds, with an IC₅₀ of 0.12 µM. All compounds exhibited moderate inhibitory effect on cytochrome CYP3A4 enzyme.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules18077336