Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer's Disease: Systematic Mini-Review

Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Alth...

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Bibliographic Details
Published inFrontiers in aging neuroscience Vol. 12; p. 591737
Main Authors Kuo, Chih-Yun, Hsiao, Hung-Ta, Lo, Ing-Hsien, Nikolai, Tomas
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 06.01.2021
Frontiers Media S.A
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Summary:Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Although the underlying mechanisms of AD are still not fully understood, a hypothesis associating OSA with AD has been already proposed. In this systematic mini-review, we first discuss the recent findings supporting the association of OSA with an increased risk of AD and then provide evidence suggesting the positive effect of OSA treatment on a reduced risk of AD.
Bibliography:content type line 23
SourceType-Scholarly Journals-1
Reviewed by: Arash Tadjalli, University of Florida, United States; Yinxia Chao, National Neuroscience Institute (NNI), Singapore
Edited by: Dennis Qing Wang, Southern Medical University, China
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2020.591737