Foot and mouth: podosomes, invadopodia and circular dorsal ruffles

The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation--which is mediated by a highly conserved actin-membrane a...

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Published inNature reviews. Molecular cell biology Vol. 5; no. 8; pp. 647 - 657
Main Authors McNiven, Mark A, Buccione, Roberto, Orth, James D
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.08.2004
Subjects
Animals
Biology
Cell Surface Extensions - physiology
Cell Surface Extensions - ultrastructure
Cells
Extracellular matrix
Humans
Kinases
Membranes
Motility
Osteoclasts - physiology
Osteoclasts - ultrastructure
Plasma
Proteins
Pseudopodia - physiology
Pseudopodia - ultrastructure
Signal Transduction - physiology
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Summary:The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation--which is mediated by a highly conserved actin-membrane apparatus--these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm1436