Omeprazole Treatment Enhances Nitrogen Use Efficiency Through Increased Nitrogen Uptake and Assimilation in Corn

Omeprazole is a selective proton pump inhibitor in humans that inhibits the H /K -ATPase of gastric parietal cells. Omeprazole has been recently shown to act as a plant growth regulator and enhancer of salt stress tolerance. Here, we report that omeprazole treatment in hydroponically grown maize imp...

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Published inFrontiers in plant science Vol. 10; p. 1507
Main Authors Van Oosten, Michael James, Dell’Aversana, Emilia, Ruggiero, Alessandra, Cirillo, Valerio, Gibon, Yves, Woodrow, Pasqualina, Maggio, Albino, Carillo, Petronia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers 04.12.2019
Frontiers Media S.A
Subjects
benzimidazole
Life Sciences
maize
nitrate reductase
nitrogen assimilation
nitrogen use efficiency
Plant Science
proton pump inhibitor
Vegetal Biology
benzimidazole
nitrate reductase
nitrogen use efficiency
maize
proton pump inhibitor
nitrogen assimilation
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Summary:Omeprazole is a selective proton pump inhibitor in humans that inhibits the H /K -ATPase of gastric parietal cells. Omeprazole has been recently shown to act as a plant growth regulator and enhancer of salt stress tolerance. Here, we report that omeprazole treatment in hydroponically grown maize improves nitrogen uptake and assimilation. The presence of micromolar concentrations of omeprazole in the nutrient solution alleviates the chlorosis and growth inhibition induced by low nitrogen availability. Nitrate uptake and assimilation is enhanced in omeprazole treated plants through changes in nitrate reductase activity, primary metabolism, and gene expression. Omeprazole enhances nitrate assimilation through an interaction with nitrate reductase, altering its activation state and affinity for nitrate as a substrate. Omeprazole and its targets represent a novel method for enhancing nitrogen use efficiency in plants.
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Edited by: Paolo Carletti, University of Padua, Italy
Reviewed by: Sara Trevisan, University of Padova, Italy; Andrew Merchant, University of Sydney, Australia; Jose M. Garcia-Mina, University of Navarra, Spain
These authors have contributed equally to this work
This article was submitted to Crop and Product Physiology, a section of the journal Frontiers in Plant Science
ISSN:1664-462X
1664-462X
DOI:10.3389/fpls.2019.01507