Watching Water Migration around a Peptide Bond

A long and winding road: The motion of a single water ligand around a peptide bond in acetanilide was probed in real time by time‐resolved IR spectroscopy. Triggered by photoionization, the H2O ligand is released from the CO site of the peptide linkage and trapped after a migration time of 5 ps at t...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 51; no. 27; pp. 6604 - 6607
Main Authors Tanabe, Kohei, Miyazaki, Mitsuhiko, Schmies, Matthias, Patzer, Alexander, Schütz, Markus, Sekiya, Hiroshi, Sakai, Makoto, Dopfer, Otto, Fujii, Masaaki
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 02.07.2012
WILEY‐VCH Verlag
Subjects
hydration
Hydrogen Bonding
hydrogen bonds
IR spectroscopy
isomerization
Models, Chemical
peptides
Peptides - chemistry
Peptides - metabolism
Permeability
Spectrophotometry, Infrared
Water - chemistry
Water - metabolism
Online AccessGet full text

Cover

More Information
Summary:A long and winding road: The motion of a single water ligand around a peptide bond in acetanilide was probed in real time by time‐resolved IR spectroscopy. Triggered by photoionization, the H2O ligand is released from the CO site of the peptide linkage and trapped after a migration time of 5 ps at the NH site of the same peptide bond (see picture).
Bibliography:MEXT
istex:BD170C510AED6B62BBFE07681F62E814FD753A53
ark:/67375/WNG-07TJG4M6-2
ArticleID:ANIE201203296
This study was supported by the MEXT (priority area 477 Japan), the Core-to-Core Program of the JSPS, and the DFG (grant number DO 729/4). We thank Kenji Sakota (Kyushu University) and Shun-ichi Ishiuchi (Tokyo Institute of Technology) for stimulating discussions. M. Schmies is grateful for an Elsa Neumann fellowship.
JSPS
DFG - No. DO 729/4
This study was supported by the MEXT (priority area 477 Japan), the Core‐to‐Core Program of the JSPS, and the DFG (grant number DO 729/4). We thank Kenji Sakota (Kyushu University) and Shun‐ichi Ishiuchi (Tokyo Institute of Technology) for stimulating discussions. M. Schmies is grateful for an Elsa Neumann fellowship.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203296