Pathological situations characterized by altered actin isoform expression
Modulation of actin isoform expression is a well‐established feature of developmental phenomena. As one might expect, it is also characteristic of several pathological situations that are the subject of the present review. α‐Smooth muscle actin has proven to be a reliable marker for identifying (a)...
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Published in | The Journal of pathology Vol. 204; no. 4; pp. 386 - 395 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.11.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Modulation of actin isoform expression is a well‐established feature of developmental phenomena. As one might expect, it is also characteristic of several pathological situations that are the subject of the present review. α‐Smooth muscle actin has proven to be a reliable marker for identifying (a) vascular smooth muscle cells during vascular development and vascular diseases, and (b) myofibroblasts during wound healing, fibrocontractive diseases, and stromal reaction to epithelial tumours. The hallmark of a differentiated myofibroblast relies on the acquisition of an organized contractile apparatus characterized by α‐smooth muscle actin‐expressing stress fibres. More and more data suggest that α‐smooth muscle actin plays a direct role in myofibroblast contractile activity through its N‐terminal domain AcEEED. Newly developed antibodies against α‐skeletal and α‐cardiac actins have allowed the detection of subpopulations of α‐skeletal positive cardiomyocytes in adult, hypertrophic, and failing heart. These antibodies have also permitted us to identify the differentiation degree of malignant cells in tumours such as rhabdomyosarcoma. Whether the differential expression of actin isoforms in human diseases is functionally relevant is not yet fully established, although studies on human actin mutations, actin null mice, and the N‐terminal end of α‐smooth muscle actin support this possibility. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
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Bibliography: | Swiss National Science Foundation - No. 31-68313.02 istex:C145C027DBA9516663D6763FA7C6469DA5DDCBC2 ark:/67375/WNG-7JVT6478-Q ArticleID:PATH1635 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0022-3417 1096-9896 |
DOI: | 10.1002/path.1635 |