St Vincent's Declaration 10 years on: outcomes of diabetic pregnancies
Aims To monitor pregnancies in women with pregestational Type 1 diabetes for pregnancy loss, congenital malformations and fetal growth parameters, in a geographically defined area in the north west of England. Methods Population cohort study of 547 pregnancies in women with Type 1 diabetes from mate...
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Published in | Diabetic medicine Vol. 19; no. 3; pp. 216 - 220 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Science Ltd
01.03.2002
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Aims To monitor pregnancies in women with pregestational Type 1 diabetes for pregnancy loss, congenital malformations and fetal growth parameters, in a geographically defined area in the north west of England.
Methods Population cohort study of 547 pregnancies in women with Type 1 diabetes from maternity clinics in 10 centres over a 5‐year period (1995–1999 inclusive). Main outcome measures were numbers and rates of miscarriages, stillbirths, neonatal and post‐neonatal deaths; prevalence of congenital malformations; birth weight in relation to gestational age.
Results Among 547 pregnancies, there were six (1.1%) pairs of liveborn twins, 439 (80.3%) liveborn singletons; 72 (13.2%) spontaneous abortions, 14 (2.6%) stillbirths and 16 (2.9%) terminations. Four of the terminations were performed because of congenital malformations. Both the stillbirth rate (30.1/1000 total births (95% confidence interval (CI) 16.6–50.0)), and prevalence of congenital malformations (84.3/1000 live births (95% CI 60.3–113.8)) were significantly higher than the local population (P < 0.001). When corrected for gestational age, mean birth weight in the sample was 1.3 sd greater than that of infants of non‐diabetic mothers (P = 0.12). Infants with congenital malformations weighed less than those without.
Conclusion In an unselected population, the infants of women with pregestational Type 1 diabetes mellitus have 6.4 times the reported risk of a congenital malformation and 5.1 times the reported risk of perinatal mortality than infants in the general population. Further improvements in the management of diabetes and pregnancy in these women are needed if the St Vincent’s Declaration target is to be met.
Diabet. Med. 19, 216–220 (2002) |
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Bibliography: | ArticleID:DME665 istex:E8856D88DD595ECE44B01FB3BBD267D1C0920A34 ark:/67375/WNG-7F4K557F-5 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0742-3071 1464-5491 |
DOI: | 10.1046/j.1464-5491.2002.00665.x |