The anti-apoptotic role of neurotensin

The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the periphery. This review summarizes studies that clearly evidenced the protective effect of neurotensin through its three known receptors. The...

Full description

Saved in:
Bibliographic Details
Published inCells Vol. 2; no. 1; pp. 124 - 135
Main Authors Devader, Christelle, Béraud-Dufour, Sophie, Coppola, Thierry, Mazella, Jean
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 04.03.2013
MDPI
Subjects
apoptosis
Life Sciences
neurotensin
receptor
Review
sortilin
Online AccessGet full text

Cover

More Information
Summary:The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the periphery. This review summarizes studies that clearly evidenced the protective effect of neurotensin through its three known receptors. The pivotal involvement of the neurotensin receptor-3, also called sortilin, in the molecular mechanisms of the anti-apoptotic action of neurotensin has been analyzed in neuronal cell death, in cancer cell growth and in pancreatic beta cell protection. The relationships between the anti-apoptotic role of neurotensin and important physiological and pathological contexts are discussed in this review.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC3972661
ISSN:2073-4409
2073-4409
DOI:10.3390/cells2010124