The Risk of Disease Progression Is Determined during the First Year of Human Immunodeficiency Virus Type 1 Infection
A cohort of 103 human immunodeficiency virus type 1 (HIV-1)-infected persons with well-defined dates of seroconversion were studied to determine whether baseline plasma HIV RNA loads 6–12 months after seroconversion have prognostic value. Baseline plasma virus loads had predictive value for the dise...
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Published in | The Journal of infectious diseases Vol. 177; no. 6; pp. 1541 - 1548 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
01.06.1998
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | A cohort of 103 human immunodeficiency virus type 1 (HIV-1)-infected persons with well-defined dates of seroconversion were studied to determine whether baseline plasma HIV RNA loads 6–12 months after seroconversion have prognostic value. Baseline plasma virus loads had predictive value for the disease-free survival rate and for the survival rate. The level of baseline HIV RNA also had a strong negative predictive value for the CD4+ T cell count during the fifth year of infection: A baseline load > 5 log was predictive of a CD4+ T cell count < 500/mm3 5 years after infection. Baseline HIV RNA load was a CD4+ T cell-independent predictor of progression to death. The major finding was that the disease outcome for HIV-1-infected persons is already determined during the first year of infection. |
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Bibliography: | ark:/67375/HXZ-GJNPQSNG-G istex:D3F50E04ADAF82AFE5A39E8E745B123F8D5D9EC7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1086/515308 |