Deciphering the lung microbiota in COVID-19 patients: insights from culture analysis, FilmArray pneumonia panel, ventilation impact, and mortality trends

• Published in: Scientific reports Vol. 14; no. 1; pp. 30035 - 10
• Main Authors: Molina, Francisco José, Botero, Luz Elena, Isaza, Juan Pablo, Cano, Luz Elena, López, Lucelly, Valdés, Luis, Arévalo Arbeláez, Angela J., Moreno, Isabel, Pérez Restrepo, Laura S., Usuga, Jaime, Ciuoderis, Karl, Hernandez, Juan Pablo, López-Aladid, Rubén, Fernández, Laia, Torres, Antoni
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.12.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326; 692/308; 692/4017; 692/699; Aged; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Biomarkers; Bronchoalveolar Lavage Fluid - microbiology; Bronchus; Coinfection - microbiology; Coinfection - mortality; Concurrent infection; COVID-19; COVID-19 - microbiology; COVID-19 - mortality; COVID-19 - virology; Female; Humanities and Social Sciences; Humans; Intensive Care Units; Lavage; Lung - microbiology; Male; Mechanical ventilation; Microbiomes; Microbiota; Microbiota - genetics; Middle Aged; Mortality; multidisciplinary; Pneumonia; Respiration, Artificial; RNA, Ribosomal, 16S - genetics; rRNA 16S; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; Science; Science (multidisciplinary); Ventilation; Ventilators

Few studies have analyzed the role of the lung microbiome in the diagnosis of pulmonary coinfection in ventilated ICU COVID-19 patients. We characterized the lung microbiota in COVID-19 patients with severe pneumonia on invasive mechanical ventilation using full-length 16S rRNA gene sequencing and e...