Reliability of patient-specific gait profiles with inertial measurement units during the 2-min walk test in incomplete spinal cord injury

• Published in: Scientific reports Vol. 14; no. 1; p. 3049
• Main Authors: Willi, Romina, Werner, Charlotte, Demkó, László, de Bie, Rob, Filli, Linard, Zörner, Björn, Curt, Armin, Bolliger, Marc
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/617/375/346; 692/700/565/491; Ankle; Gait; Humanities and Social Sciences; multidisciplinary; NCT; NCT04555759; Neurological diseases; Science; Science (multidisciplinary); Spinal cord injuries; Walking
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-53301-y

Most established clinical walking tests assess specific aspects of movement function (velocity, endurance, etc.) but are generally unable to determine specific biomechanical or neurological deficits that limit an individual’s ability to walk. Recently, inertial measurement units (IMU) have been used to collect objective kinematic data for gait analysis and could be a valuable extension for clinical assessments (e.g., functional walking measures). This study assesses the reliability of an IMU-based overground gait analysis during the 2-min walk test (2mWT) in individuals with spinal cord injury (SCI). Furthermore, the study elaborates on the capability of IMUs to distinguish between different gait characteristics in individuals with SCI. Twenty-six individuals (aged 22–79) with acute or chronic SCI (AIS: C and D) completed the 2mWT with IMUs attached above each ankle on 2 test days, separated by 1 to 7 days. The IMU-based gait analysis showed good to excellent test–retest reliability (ICC: 0.77–0.99) for all gait parameters. Gait profiles remained stable between two measurements. Sensor-based gait profiling was able to reveal patient-specific gait impairments even in individuals with the same walking performance in the 2mWT. IMUs are a valuable add-on to clinical gait assessments and deliver reliable information on detailed gait pathologies in individuals with SCI. Trial registration: NCT04555759.