Absence of Toll-Like Receptor 4 Signaling Results in Delayed Yersinia enterocolitica YopP-Induced Cell Death of Dendritic Cells

In an initial period (<=4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates...

Full description

Saved in:
Bibliographic Details
Published inInfection and Immunity Vol. 75; no. 1; pp. 512 - 517
Main Authors Gröbner, Sabine, Schulz, Sebastian, Soldanova, Irena, Gunst, Dani S.J, Waibel, Michaela, Wesselborg, Sebastian, Borgmann, Stefan, Autenrieth, Ingo B
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.2007
Subjects
Animals
Apoptosis - physiology
Bacterial Proteins - immunology
Bacteriology
Biological and medical sciences
Caspase 8 - metabolism
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Dendritic Cells - microbiology
Dendritic Cells - pathology
Enzyme Activation - immunology
Fundamental and applied biological sciences. Psychology
Immunoblotting
Mice
Microbiology
Miscellaneous
Signal Transduction - immunology
Toll-Like Receptor 4 - metabolism
Yersinia enterocolitica
Yersinia enterocolitica - immunology
Yersinia Infections - immunology
Yersinia enterocolitica
Dendritic cell
Microbiology
Cell death
Bacteria
Toll like receptor
Immunity
Enterobacteriaceae
Online AccessGet full text

Cover

More Information
Summary:In an initial period (<=4 h) Toll-like receptor 4 (TLR4) signaling is required for Yersinia enterocolitica YopP-induced dendritic cell (DC) death. Later (>4 h), DC die independent of TLR4 signaling. In TLR4-deficient DC caspase 8 cleavage is delayed, indicating that TLR4 signaling accelerates caspase 8 activation, leading to DC death.
Bibliography:http://iai.asm.org/
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Editor: J. B. Bliska
Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, Eberhard Karls University of Tübingen, Elfriede-Aulhorn-Str. 6, D-72076 Tübingen, Germany. Phone: 49 7071 29 81528. Fax: 49 7071 29 5440. E-mail: sabine.groebner@med.uni-tuebingen.de.
S.G. and S.S. contributed equally to this work.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.00756-06