The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is still a public health disease with its high prevalence and morbidity. Short of early diagnosis biomarkers and effective therapy, the treatment of HCC patients hasn’t achieved ideal effect. Hypoxia is a hallmark of HCC, which is mainly induced by imbalance of tumor c...

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Published inDiscover. Oncology Vol. 15; no. 1; p. 144
Main Authors Wang, Xuejing, Wang, Xiaojun
Format Journal Article
LanguageEnglish
Published New York Springer US 07.05.2024
Springer Nature B.V
Springer
Subjects
Angiogenesis
Apoptosis
Biomarkers
Cancer Research
Cancer therapies
Glucose
Hepatocellular carcinoma
Hypoxia
Internal Medicine
Kinases
Liver cancer
lncRNA
Medicine
Medicine & Public Health
Metabolism
Metabolites
Metastasis
MicroRNAs
Molecular Medicine
Oncology
Prognosis
Proteins
Radiotherapy
Review
Stem cells
Surgical Oncology
Biomarkers
Hepatocellular carcinoma
Hypoxia
lncRNA
Prognosis
Metastasis
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Summary:Hepatocellular carcinoma (HCC) is still a public health disease with its high prevalence and morbidity. Short of early diagnosis biomarkers and effective therapy, the treatment of HCC patients hasn’t achieved ideal effect. Hypoxia is a hallmark of HCC, which is mainly induced by imbalance of tumor cell proliferation and insufficient supply of oxygen. Recently, amounting evidence suggested lncRNAs, especially hypoxia-related lncRNAs play a pivotal role in regulating HCC. Hypoxia-related lncRNAs are involved in altering glucose metabolism, maintaining of cancer stem cell-like properties (CSCs), cell apotosis, proliferation and immune escape, which all contribute to the poor prognosis of HCC patients. The novel identified hypoxia-related lncRNAs could be the potential target or biomarkers of HCC, which are beneficial to the clinical treatment. Herein, we summarized currently reported hypoxia-related lncRNAs and their related mechanisms, providing potential application and future perspective of hypoxia-related lncRNAs as a potential therapeutic target.
Bibliography:ObjectType-Article-2
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ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-024-01002-3