Metabolic surgery versus conventional therapy in type 2 diabetes

• Published in: The Lancet (British edition) Vol. 397; no. 10271; pp. 256 - 257
• Main Authors: Miras, Alexander D, le Roux, Carel W
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 23.01.2021; Elsevier Limited
• Subjects: Bariatric Surgery; Clinical trials; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Drug therapy; Follow-Up Studies; Glucose; Glycated Hemoglobin A - analysis; Humans; Insulin; Metabolism; Patients; Pharmacology; Remission; Surgery
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(21)00129-X

Taken together, addressing an important knowledge gap is changing the attitudes of both patients and diabetologists. [...]during the past 12 years, 12 other randomised controlled trials have shown consistent findings,4 thus providing confidence in the robustness of the data. Dr P Marazzi/Science Photo Library The trial by Mingrone and colleagues has several strengths besides the long-term follow-up.1 Patients included had advanced type 2 diabetes, with half of them taking insulin at baseline. [...]detailed information was provided about intensity of lifestyle modification and pharmacotherapy throughout the trial for the medical therapy group. Another limitation was that type 2 diabetes remission was defined as euglycaemia without pharmacotherapy. [...]it was probably impossible for patients in the medical group to ever go into remission considering how advanced their disease was.