HMGCS2 and AMACR as potential targets linking mitochondrial dysfunction and ulcerative colitis

• Published in: Scientific reports Vol. 14; no. 1; pp. 31783 - 15
• Main Authors: Zhu, Rui, Bai, Xinyu, Li, Zhangqin, Liang, Hao, Song, Huixian, Chen, Lifang, Miao, Yinglei, Zhang, Fengrui, Niu, Junkun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.12.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/129; 631/114/1305; 692/4020; 692/53; 692/699; Animals; Colitis, Ulcerative - genetics; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Gene expression; Gene Expression Profiling; Gene Regulatory Networks; Genes; Homeostasis; Humanities and Social Sciences; Humans; Immune infiltration; Inflammatory bowel disease; Inflammatory bowel diseases; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Machine Learning; Mice; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mucosa; multidisciplinary; Science; Science (multidisciplinary); Structure-function relationships; Ulcerative colitis; WGCNA; Mitochondria; WGCNA; Machine learning; Immune infiltration; Ulcerative colitis

Ulcerative colitis (UC) is characterised notably by an imbalance in intestinal mucosal homeostasis. Although mitochondrial dysfunction has been identified as a potential contributor to this imbalance, it remains an incomplete understanding. Consequently, further investigation into the role of mitoch...