No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise

• Published in: Journal of applied genetics Vol. 64; no. 1; pp. 81 - 87
• Main Authors: Światowy, Witold Józef, Zieliński, Jacek, Osielska, Maria Aleksandra, Kusy, Krzysztof, Wieliński, Dariusz, Pławski, Andrzej, Jagodziński, Paweł Piotr
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2023; Springer; Springer Nature B.V
• Subjects: Adaptation; Animal Genetics and Genomics; Athletes; Biomedical and Life Sciences; Blood cells; Cellular structure; DNMT1 protein; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Ethylenediaminetetraacetic acid; Exercise; Gene expression; Genes; Genetic research; Genetic transcription; Human Genetics; Human Genetics • Original Paper; Humans; Leukocytes, Mononuclear; Life Sciences; Metabolism; Methyltransferases; Microbial Genetics and Genomics; Monocytes; Peripheral blood mononuclear cells; Physical exercise; Physiological aspects; Plant Genetics and Genomics; Recovery; RNA; RNA, Messenger; Treadmills; Poland; Germany; DNA methylation; Acute exercise; DNMT1; Epigenetic; HDAC1; JHDM1D
• ISSN: 1234-1983; 2190-3883
• DOI: 10.1007/s13353-022-00736-6

Physical exercise results in structural remodeling in tissues and modifies cellular metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic changes are one of the factors responsible for such exercise-related alterations. One-hour acute exercise will change DNMT1, HDAC1, and JHDM1D transcriptions in PBMC. This study examined changes in the expression of genes responsible for epigenetic modifications (HDAC1, DNMT1, and JHDM1D) during and after an incremental exercise test on a treadmill and a 30-min recovery. Blood samples from 9 highly trained triathletes were tested. Examination of the transcripts showed no significant changes. Correlations between transcript results and biochemical indices revealed a significant ( p  = 0.007) relationship between JHDM1D mRNA and the number of monocytes at peak exercise intensity (exhaustion), while there was no significant ( p  = 0.053) correlation at rest. There are no rapid changes in the mRNA levels of the genes studied in blood cells in competitive athletes during acute exercise and recovery. Due to the small group of subjects studied, more extensive research is needed to verify correlations between transcription and biochemical variables.