Severe Neutropenia During Therapy for Concurrent Primary Human Immunodeficiency Virus and Cytomegalovirus Infections

Treatment of primary HIV infection with antiretrovirals is based on theoretical rationale, limited clinical trial data, and the opinions of experts. We describe a patient with concurrent primary HIV-1 and cytomegalovirus (CMV) infections who had severe neutropenia while receiving antiretroviral ther...

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Published inClinical infectious diseases Vol. 28; no. 4; pp. 920 - 921
Main Authors Sutinen, Jussi, Ristola, Matti, Suni, Jukka, Nuutinen, Hannu, Lähdevirta, Juhani
Format Journal Article Conference Proceeding
LanguageEnglish
Published Chicago, IL The University of Chicago Press 01.04.1999
University of Chicago Press
Subjects
Adult
Anti-HIV Agents - adverse effects
Antibodies
Antiretrovirals
Biological and medical sciences
Brief Reports
Cytomegalovirus
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - drug therapy
Drug Therapy, Combination
Drug toxicity and drugs side effects treatment
Female
HIV
HIV 1
HIV Infections - complications
HIV Infections - drug therapy
Human cytomegalovirus
Human immunodeficiency virus
Humans
Infections
Medical sciences
Neutropenia
Neutropenia - etiology
Neutrophils
Pharmacology. Drug treatments
RNA
Serology
Toxicity: blood
Human
Immunopathology
Opportunistic infection
Toxicity
Herpesviridae
AIDS
Hemopathy
Betaherpesvirinae
Immune deficiency
Human cytomegalovirus
Esophagus
Infection
Virus
Case study
Chemotherapy
Treatment
Viral disease
Antiviral
Ulcer
Neutropenia
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Summary:Treatment of primary HIV infection with antiretrovirals is based on theoretical rationale, limited clinical trial data, and the opinions of experts. We describe a patient with concurrent primary HIV-1 and cytomegalovirus (CMV) infections who had severe neutropenia while receiving antiretroviral therapy. Serologies for antibodies to CMV and HIV and testing to determine plasma HIV RNA viral load (Amplicor HIV Monitor Test, Roche Diagnostic Systems, Branchburg, NJ) were done with use of commercial kits. A search was performed on MEDLINE and AIDSLINE through November 1997 for concurrent acute/primary infections with HIV and CMV. Additional cases were identified by manual searches.
Bibliography:istex:63953A3319AB019F31651403BB19DFBEFDBAE614
Reprints or correspondence: Dr. Matti Ristola, Aurora Hospital, P.O. Box 348, FIN-00029 HYKS, Finland.
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ISSN:1058-4838
1537-6591
DOI:10.1086/517246